Research Technician
Research Technician
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Job Description
Neurodegenerative Diseases Research Group
Our group is looking for candidates to fill in a research technician position. The candidate will provide support in projects related to the mechanisms of interorgan communication in Parkinsons disease to elish novel pathogenic mechanisms and new possibilities for biomarkers and diseasemodifying theutic strategies.
Parkinsons disease (PD) is a common progressive human neurodegenerative disorder of unknown origin that is becoming more frequent due to the increase in life expectancy. Importantly there are no reliable biomarkers that allow an early diagnosis nor therapies that stop or slow down its progression so it remains an incurable disease.
This project looks more deeply into the communication between the brain and other body organs in PD. Current diagnosis requires the identification of clical motor symptoms first noticeable when there is already a significant neuronal loss in susceptible brain regions. However PD patients present with other nonmotor symptoms (NMS) that usually appear clinically before the manifestation of parkinsonism in a prediagnostic phase of several years. These include gastrointestinal alterations and other alterations of the autonomic nervous system. Also an altered microbiota composition has been reported in the gut of PD patients. The main aim is to understand how alterations in the gutbrain axis and other communication axis (i.e. neuroendocrine immune and metabolic) contribute to the onset and/or progression of disease with the goal of identifying possible early biomarkers and new therapies to prevent or slow down disease progression.
The transversal position offered ranges from the ysis of human biological samples and clinical data from patients to the basic understanding of the cellular and molecular mechanisms underlying Parkinsons disease in rodent and cellular models.
Education and qualifications:
Required:
- Bachelors Degree in Health/Life Sciences.
- Completed Masters degree in Neurosciences Translational Biomedicine Research Microbiology or similar.
- Good communication ss and fluency in spoken and written English.
- Experience and knowledge of basic laboratory histological techniques (e.g. stereological cell ysis IHC IF confocal microscopy) and molecular techniques (ELISA RTqPCR WB Dot Blot).
Desired:
- Previous knowledge in the field of neurodegenerative diseases specifically in Parkinsons Disease.
- Certification and experience working with animal models and knowledge of animal experimentation techniques (stereotaxic injection of AdenoociatedViral Vectors (AAV) behavioral tests).
- Previous experience processing human and animal samples (brain tissue and biofluids).
- Experience in specific software for image and data ysis (OlyVIA Image J GraphPad Stata).
Experience and knowledge:
Required:
- Previous experience in basic laboratory techniques.
- Proactive dynamic and outstanding organizational ss.
- Strong sense of responsibility initiative selfmotivation and social ss as key personal abilities.
- Ability to work independently as well as in a team environment.
Desired:
- Previous experience with Neurosciences Immunology or Microbiology.
- Experience in handling human cell and mouse samples.
- Author of scientific publications.
- Research experience abroad.
Main responsibilities and duties:
- Manipulation and surgery of mice and rats to generate and characterize rodent Parkinsons disease models
- Process human and mouse samples (histology microscopy biochemical and molecular yses)
- yze and interpret the data generated
- Careful reading of the literature to provide intellectual input to the research project
- Participation in group meetings and scientific seminars
- ysis of inflammation and barrier biomarkers in tissue samples obtained from the VHIP cohort.
- Correlation of the different biomarkers detected with demographic and clinical parameters of the VHIP cohort.
Labour conditions:
- Parttime position: 30h/week
- Starting date: October 2024
- Gross annual salary: 17.11742 euros (Remuneration will depend on experience and ss. Salary ranges are consistent with our Collective Agreement pay scale)
- Contract: temporary
What can we offer
- Incorporation to Vall dHebron Research Institute (VHIR) a public sector institution that promotes and develops the biomedical research innovation and teaching at Vall dHebron University Hospital (HUVH) the biggest hospital of Barcelona and the largest of Catalan Institute of Health (ICS).
- A scientific environment of excellence highly dynamic where highend biomedical projects are continuously developed.
- Continuous learning and a wide range of responsibilities within a stimulating work environment.
- Individual training opportunities.
- Flexible working hours.
- 23 days of holidays 9 personal days.
- Flexible Remuneration Program (including dining checks health insurance transportation and more)
- Corporate Benefits: platform through which you can obtain significant discounts on travel culture technology gastronomy sports... among many others.
- Healthy Offering: choose from a variety of wellbeing focused activities to be the healthiest you.
Deadline to apply:
VHIR embraces Equality and Diversity. As reflected in our values we work toward ensuring inclusion and equal opportunity in recruitment hiring training and management for all staff within the organization regardless of gender civil status family status sexual orientation gender identity and expression religion age functional diversity or ethnicity.
Employment Type
Full Time
