PBPK Modelerall genders permanent full-time

The job that makes possibilities real in patients lives. And yours.

The job that helps you get ahead in life. Moving mountains together.

Welcome to AbbVie! As part of an international company with 48000 employees worldwide and around 3000 employees in Germany you will have the opportunity of addressing some of tomorrows unmet medical needs in close collaboration with your colleagues. Are you passionate about improving global health care Do you want to contribute to improving patients quality of life through your expertise In a challenging work environment that offers opportunities of developing and increasing your own skills Youve come to the right place!

Moving mountains together as PBPK Modeler (all genders) (permanent / fulltime)

The Quantitative Translational and ADME Sciences (QTAS) team at AbbVie Inc. is seeking a scientist in the Germany who can perform a role as PhysiologicallyBased Pharmacokinetics (PBPK) modeler to provide small molecule project support across multiple therapeutic areas. The successful candidate will be responsible for conducting static and mechanistic PBPK human PK and drugdrug interactions (DDI) projections using in vitro and in vivo ADME/PK data to support Discovery and Development project teams enabling compound progression from discovery to early stages of clinical development. The position will require close collaboration with lab functions within QTAS Discovery project teams and other R&D stakeholders in order to develop and execute QTAS strategies necessary to select and facilitate the advancement of optimized candidate molecules. In this exciting and dynamic role you will also be expected to evaluate new technologies and approaches to support the mechanistic and translational understanding of drug disposition and drugdrug interactions. The ideal candidate will have strong background and handson experiences in PBPK modeling using a commercial software (e.g. Simcyp).

Responsibilities

• Predict human PK and DDI profiles of small molecule drug candidates utilizing preclinical in vitro and in vivo ADME/PK data and static and mechanistic modeling tools
• Support project teams across multiple therapeutic areas and interpret results through close partnership with QTAS representatives
• Effectively communicate human PK/DDI prediction and PBPK modeling QTAS strategy and knowledge to project teams functional leaders and other key stakeholders to ensure alignment and influence decisions
• Demonstrate thorough understanding of drug metabolism pharmacokinetics and bioanalysis (DMPKBA) necessary for the characterization of small molecule drug candidates to support regulatory submissions
• Stay current with latest developments in the field of human PK and DDI predictions including empirical (e.g. allomeric scaling) and more mechanistic models (e.g. PBPK)

Qualifications :

• Doctorate (Ph.D.) in Pharmaceutical Sciences Pharmacokinetics Pharmacology Biomedical Engineering or related field with at least 2 years of experience in the pharmaceutical or biotechnology industries
• Experience with relevant modeling software including Simcyp and Phoenix WinNonlin is required
• Handson project experience in PBPK modeling and simulation through direct industry experience as well as knowledge of regulatory expectations regarding PBPK modeling is preferred
• Experience in the field of DMPK with a general understanding of one or more disciplines within DMPK and knowledgeable in one or more of the following areas: in vitro ADME pharmacokinetics transporter DDI translational modeling biotransformation biomarker strategy
• Demonstrated publication record; lead/senior author contributions a plus
• Ability to influence negotiate and communicate effectively with both internal and external stakeholders; ability to work well in a collaborative fastpaced team environment
• Highly motivated selfdriven and resultsoriented with excellent communication and presentation skills; capable of working both as team player and project driver
• High degree of flexibility in adapting to different projects and people; excellent networking and relationshipbuilding (both internal and external) skills
• Passion for data analysis solving technical problems and applying new technologies to further scientific goals

Key Leadership Competencies:

• Builds strong relationships with peers and crossfunctionally with partners outside of team to enable higher performance
• Learns fast grasps the essence and can change course quickly where indicated
• Raises the bar and is never satisfied with the status quo
• Creates a learning environment open to suggestions and experimentation for improvement
• Embraces the ideas of others nurtures innovation and manages innovation to reality

Heres how we can move mountains together

• with a diverse work environment where you can have a real impact
• with an open corporate culture
• with an attractive salary
• with an intensive onboarding process with a mentor at your side
• with flexible work models for a healthy worklife balance
• with a corporate health management that offers comprehensive health and exercise programs
• with company social benefits
• with a wide range of career opportunities in an international organization
• with toptier attractive development opportunities
• with a strong international network

Multiple times we have been globally recognized as a Great Place to Work and we are proud to provide our employees with the flexibility to maintain a healthy worklife balance. We take our impact on the environment and our communities seriously and therefore focus on giving something back on a regular basis. We are committed to equality equity diversity and inclusion (EED&I) a commitment that is fundamental to us. This includes appreciating different perspectives creating an inclusive culture and treating all employees with dignity and respect.

At AbbVie your individual contributions count help us move mountains together. Be a part of our success grow with us and accomplish more than you could have imagined. Sounds like the perfect career opportunity for you We look forward to receiving your application! All you need is a complete CV we will discuss everything else with you in person.

Have questions Email We look forward to hearing from you! 

Additional Information :

AbbVie is an equal opportunity employer and is committed to operating with integrity driving innovation transforming lives serving our community and embracing diversity and inclusion.  It is AbbVies policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race color religion national origin age sex (including pregnancy) physical or mental disability medical condition genetic information gender identity or expression sexual orientation marital status status as a protected veteran or any other legally protected group status.

US & Puerto Rico only to learn more visit ;

US & Puerto Rico applicants seeking a reasonable accommodation click here to learn more: