Vice President Head of Translational Sciences
Vice President Head of Translational Sciences
Posted on :
16-02-2025
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Job Description
Job Title: Vice President Head of Translational Sciences
Job Location: Little Abington Cambridge CB21 UK
Job Location Type: Hybrid
Job Contract Type: Fulltime
Job Seniority Level: Director
Amphista is a leading Europebased biotech applying a pioneering next generation Targeted Protein Degradation technology to the discovery of therapeutics for human diseases. We are now advancing programs into the clinical development phase with the aim of bringing transformational medicines to patients. For more information please visit:
Position:
We are seeking a highly talented and experienced Vice President Head of Translational Sciences who shares our excitement about Amphista’s therapeutic portfolio is passionate about advancing therapeutics champions our culture and supports our commitment to transforming patients’ lives. You will be a visionary expert in translational science with the ability to execute a successful strategy to deliver the progression of Amphista’s portfolio of therapeutics.
Requirements:
Responsibilities:
What’s On Offer
Amphista’s approaches use completely novel mechanisms to build on all the advantages of TPD while directly addressing the emerging limitations of existing TPD strategies to expand the utility of the field. We have shown our approach has the potential to be superior to all other TPD approaches (PROTACs molecular glues etc) improved druglike properties and reduced tumour resistance potential. We have a range of projects in the discovery phase initially focused on oncology with potential to expand into other therapy areas including CNS disease & immunology.
Initially founded from the laboratory of Professor Alessio Ciulli (University of Dundee) our team comprises both academic and drug discovery pioneers of the TPD field and a growing R&D team focused on advancing a portfolio of medicines to the clinic using our proprietary next generation TPD technologies. We are continuing to grow and are looking for a key hire to expand our screening and assay teams.
The Amphista team comprises highly experienced drug discovery and TPD experts across both biology and chemistry disciplines creating the ideal learning environment to advance your scientific career development quickly. This is an exciting opportunity to join a fast growing and dynamic company operating at the cutting edge of protein degradationbased drug discovery to develop firstinclass medicines to treat cancer and other areas of high unmet medical need.
Position:
We are seeking a highly talented and experienced Vice President Head of Translational Sciences who shares our excitement about Amphista’s therapeutic portfolio is passionate about advancing therapeutics champions our culture and supports our commitment to transforming patients’ lives. You will be a visionary expert in translational science with the ability to execute a successful strategy to deliver the progression of Amphista’s portfolio of therapeutics.
Requirements:
Responsibilities:
- Provide strategic leadership and guidance to project teams and the R&D leadership team enabling the development and execution of translational strategies to support the progression of Amphista’s portfolio of novel differentiation therapeutics
- Partner with project teams to identify and establish disease biomarkers to support decision making in the clinical development programs. This will include the identification and validation of biomarkers of target engagement/pharmacodynamics disease processes/mechanisms patient stratification and clinical response prediction.
- Implement validated biomarkers in First in Human and Proof of Concept clinical trials in oncology including data interpretation by working with internal stakeholders and external providers such as clinical CROs
- Establish and maintain strategic collaborations with academic institutions CROs and other external partners to access cuttingedge technologies tools reagents biosamples biomarker expertise and research capabilities.
- Build and maintain a network of external experts to stay at the cutting edge of biomarker advancements in the diseases of relevance to Amphista’s therapeutic portfolio
- Extensive experience in translational science and biomarker development in biotech or pharma industry
- Extensive understanding of oncology and a working understanding of hematological oncology
- Experience in translational/biomarkers implementation in the clinical setting underpinned by a broad knowledge of technologies and methods used in translational research
- Proven track record of implementing biomarker strategies through external service providers and delivering translational science insights to support drug development
- Experience leading/managing external collaborations and maintaining relationships with diverse external service providers and expert advisors
- Familiarity with bioinformatic/computational methods used in integrated analysis and interpretation of translational and clinical biomarkerrelated data sets.
- Knowledge of regulatory requirements industry standards best practices and compliance considerations in translational research and biomarker development and validation.
- PhD in a relevant scientific discipline
What’s On Offer
- Competitive salary
- Flexible Benefits including Private Medical Insurance Life Assurance at 4 x Salary Critical Illness Cover holiday buy scheme and a Health Cash Plan
- Discretionary Bonus Scheme
- Allocation of Growth Shares
- Pension scheme with 5% employer matched contribution
- 25 days holiday bank holidays
Amphista’s approaches use completely novel mechanisms to build on all the advantages of TPD while directly addressing the emerging limitations of existing TPD strategies to expand the utility of the field. We have shown our approach has the potential to be superior to all other TPD approaches (PROTACs molecular glues etc) improved druglike properties and reduced tumour resistance potential. We have a range of projects in the discovery phase initially focused on oncology with potential to expand into other therapy areas including CNS disease & immunology.
Initially founded from the laboratory of Professor Alessio Ciulli (University of Dundee) our team comprises both academic and drug discovery pioneers of the TPD field and a growing R&D team focused on advancing a portfolio of medicines to the clinic using our proprietary next generation TPD technologies. We are continuing to grow and are looking for a key hire to expand our screening and assay teams.
The Amphista team comprises highly experienced drug discovery and TPD experts across both biology and chemistry disciplines creating the ideal learning environment to advance your scientific career development quickly. This is an exciting opportunity to join a fast growing and dynamic company operating at the cutting edge of protein degradationbased drug discovery to develop firstinclass medicines to treat cancer and other areas of high unmet medical need.
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Employment Type
Full Time
Key Skills
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