Postdoctoral Researcher - Pancreatic Cancer
Postdoctoral Researcher - Pancreatic Cancer
Employer Active
Job Alert
You will be updated with latest job alerts via email
Share
Job Alert
You will be updated with latest job alerts via email
Job Description
Union: NonUnion
Site: Princess Margaret Cancer Centre
Department: Cancer Biology & Imaging Program
Reports to: Principal Investigator
Work Model: OnSite
Grade: V0:90
Hours: 37.5 hours per week
Salary: $60000 minimum annually: To commensurate with experience and consistent with UHN compensation policy
Shifts: Monday Friday
Status: Temporary Full Time (12months with option to extend beyond 1 year and convert to permanent position)
Closing Date: December 31 2024 (repost)
Position Summary
The DaCosta Research Lab at the Princess Margaret Cancer Centre (PMCC) () is currently seeking a Postdoctoral Fellow to join our preclinical pancreatic cancer research team.
The successful applicant will be part of a research group that uses intravital fluorescence microscopy imaging in live animals to study pancreatic cancer initiation biology progression and response to novel radiotherapeutic treatment strategies using advanced animal models of cancer within the mouse pancreas. The successful applicant will help to study the pancreatic tumor microenvironment in an orthotopic setting with a focus on tumor vasculature hypoxia immune cells stroma and other key aspects in vivo. An important area to investigate when in this role will include the study of novel radiosensitizers and their role in pancreatic treatment response. A key additional focus area will be on the use of immune and cell therapies for treatment of pancreatic cancer.
The successful applicant will also collaborate extensively with other labs across UHN as well as external collaborators. The position status is temporary fulltime (1 year) with the potential to extend to permanent fulltime based on the candidates performance and compatibility with the research team and lab objectives. The ideal candidate will have a clear career plan to become a principal investigator or independent scientist seeking an academic faculty position.
Primary Duties
- Perform rodent microsurgeries to inoculate cells install imaging devices or other procedures as necessary
- Intravital imaging of rodents using various techniques including but not limited to widefield imaging confocal and multiphoton microscopy bioluminescent imaging (BLI) computed tomography (CT) and magnetic resonance imaging (MRI)
- Develop and conduct experiments evaluating new pancreatic cancer treatment strategies such as immunotherapies smallmolecule inhibitors transplantations and radiation
- Propose new research directions and create projects
- Troubleshoot evaluate and adjust protocols as necessary to improve data quality or in response to experimental needs
- Maintain experimental cell lines and develop new reporter variants as necessary
- Run molecular biology protocols including but not limited to immunohistochemistry flow cytometry ELISA qPCR and Western Blot
- Maintain complete and accurate documentation of data generated and work performed on behalf of the lab
- Adhere to Quality Control and Quality Assurance programs to support the effective operation of the lab and to maintain appropriate laboratory standards
- Aid in writing competitive peerreviewed research grants relevant to the lab
- Write and publish peerreviewed scientific publications regarding this research
- Cosupervise graduate and summer students with the Principal Investigator and other PDFs
Qualifications :
- Completion of a doctoral degree (PhD) from a recognized institution
- Strong background (minimum 3 years) in cancer biology and immunology with a publication record is required
- Excellent track record of publication productivity in medium to high impact journals in the field
- Track record in writing successful competitive peerreviewed research grants
- Excellent animal handling and microsurgery skills are required
- Experience with animal microsurgery considered an asset
- Strong familiarly with molecular and cellular laboratory techniques e.g. cell culture virus transduction ELISA flow cytometry immunohistochemistry is required
- Experience with in vivo imaging techniques particularly confocal and/or multiphoton microscopy is highly preferred
- Welldeveloped computer skills and/or the ability to learn new computer programs for analyzing imaging data (e.g. IMARIS HALO ImageJ) are an asset
- Excellent problem recognition critical thinking organizational detailfocused and problemsolving skills
- Ability to work independently and as a team member
- Excellent verbal presentation and written communication skills
- Experience in supervising and mentoring undergraduate and/or graduate students
- Experience in managing research projects effectively on time and within budget
Additional Information :
Why join UHN
In addition to working alongside some of the most talented and inspiring healthcare professionals in the world UHN offers a wide range of benefits programs and perks. It is the comprehensiveness of these offerings that makes it a differentiating factor allowing you to find value where it matters most to you now and throughout your career at UHN.
- Competitive offer packages
- Government organization and a member of the Healthcare of Ontario Pension Plan (HOOPP )
- Close access to Transit and UHN shuttle service
- A flexible work environment
- Opportunities for development and promotions within a large organization
- Additional perks (multiple corporate discounts including: travel restaurants parking phone plans auto insurance discounts onsite gyms etc.)
Current UHN employees must have successfully completed their probationary period have a good employee record along with satisfactory attendance in accordance with UHNs attendance management program to be eligible for consideration.
All applications must be submitted before the posting close date.
UHN uses email to communicate with selected candidates. Please ensure you check your email regularly.
Please be advised that a Criminal Record Check may be required of the successful candidate. Should it be determined that any information provided by a candidate be misleading inaccurate or incorrect UHN reserves the right to discontinue with the consideration of their application.
UHN is an equal opportunity employer committed to an inclusive recruitment process and workplace. Requests for accommodation can be made at any stage of the recruitment process. Applicants need to make their requirements known.
We thank all applicants for their interest however only those selected for further consideration will be contacted.
Remote Work :
No
Employment Type :
Fulltime
Employment Type
Full-time
