Postdoctoral Researcher - Leukemia
Postdoctoral Researcher - Leukemia
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Job Description
Union: Non Union
Site: Princess Margaret Cancer Centre UHN
Department: Cancer Biology & Imaging Program
Reports to: Principal Investigator
Work Model: Monday Friday
Grade: V0:90
Hours: 37.5 hours per week
Salary: $53303 minimum annually: To commensurate with experience and consistent with UHN compensation policy
Shifts: Monday Friday
Status: Temporary Full Time (1year with option to extend and/or convert to permanent position)
Closing Date: December 31 2024 (repost)
Position Summary
The DaCosta Research Lab at the Princess Margaret Cancer Centre (PMCC) () is currently seeking a Postdoctoral Fellow to join our preclinical leukemia research team. The successful applicant will report directly to Dr. DaCosta. The successful applicant will be part of a group that uses intravital fluorescence microscopy imaging to study leukemia initiation biology propagation and response to novel treatment strategies using advanced animal models of disease for example within the mouse bone marrow. The successful applicant will also collaborate extensively with other leukemia labs across the University Health Network as well as external collaborators. The position status is temporary fulltime (1 year) with the potential to extend to permanent fulltime based on the candidates performance and compatibility with the research team and lab objectives.
The ideal candidate will have a clear career plan to become a principal investigator or independent scientist seeking an academic faculty position.
Primary Duties:
- Work closely with other PDFs in the DaCosta lab to help lead hematopoietic stem cell (HSC) and leukemiarelated research projects (including but not limited to conceptualizing project aims developing a projected timeline for experiments preparing research updates ensuring that there is communication and organization amongst members of the preclinical team through internal meetings)
- Intravital imaging of rodents using various techniques including but not limited to widefield imaging confocal and multiphoton microscopy bioluminescent imaging (BLI) computed tomography (CT) and magnetic resonance imaging (MRI)
- Develop and conduct experiments evaluating new leukemia treatment strategies such as immunotherapies smallmolecule inhibitors transplantations and radiation
- Produce timely and rigorously written scientific and other publications related to the research undertaken
- Conceive new research directions build new projects and participate in grant writing for the lab as necessary
- Troubleshoot evaluate and adjust protocols as necessary to improve data quality or in response to experimental needs
- Run molecular biology protocols including but not limited to flow cytometry ELISA qPCR and Western Blot
- Maintain complete and accurate documentation of data generated
- Adhere to Quality Control and Quality Assurance programs to support the effective operation of the lab and to maintain appropriate laboratory standards
- Take a leadership role with PI and other PDFs in the DaCosta lab to write competitive research grants related to lab projects
- Help foster new collaborations with relevant partners and maintain existing collaborations
Qualifications :
- Completion of a doctoral degree (PhD) from a recognized and competitive institution
- Strong background (> 3 years) in hematologic cancer biology (specifically HSCs and leukemia in the bone marrow microenvironment) and immunology with a compelling peerreviewed scientific publication record is required
- Animal handling and microsurgery skills are required
- Strong familiarly with molecular and cellular laboratory techniques e.g. cell culture virus transduction ELISA flow cytometry immunohistochemistry is required
- Experience with in vivo imaging techniques (intravital) particularly confocal and/or multiphoton optical microscopy is highly preferred
- Welldeveloped computer skills and/or the ability to learn new computer programs for analyzing imaging data (e.g. IMARIS HALO ImageJ are an asset)
- Ability to scientifically plan experiments and rigorously analyze data and work collaboratively with various research partners
- Good statistical analysis knowledge is required
- Excellent problem recognition critical thinking organizational detailfocused and problemsolving skills
- Ability to work independently and as a team member in a collaborative manner
- Excellent verbal and written communication skills including scientific writing skills evidenced by publication record
- Ability to advise guide and mentor students (e.g. summer/graduate students)
Additional Information :
Why join UHN
In addition to working alongside some of the most talented and inspiring healthcare professionals in the world UHN offers a wide range of benefits programs and perks. It is the comprehensiveness of these offerings that makes it a differentiating factor allowing you to find value where it matters most to you now and throughout your career at UHN.
- Competitive offer packages
- Government organization and a member of the Healthcare of Ontario Pension Plan (HOOPP )
- Close access to Transit and UHN shuttle service
- A flexible work environment
- Opportunities for development and promotions within a large organization
- Additional perks (multiple corporate discounts including: travel restaurants parking phone plans auto insurance discounts onsite gyms etc.)
All applications must be submitted before the posting close date.
UHN uses email to communicate with selected candidates. Please ensure you check your email regularly.
Please be advised that a Criminal Record Check may be required of the successful candidate. Should it be determined that any information provided by a candidate be misleading inaccurate or incorrect UHN reserves the right to discontinue with the consideration of their application.
UHN is an equal opportunity employer committed to an inclusive recruitment process and workplace. Requests for accommodation can be made at any stage of the recruitment process. Applicants need to make their requirements known.
We thank all applicants for their interest however only those selected for further consideration will be contacted.
Remote Work :
No
Employment Type :
Contract
Employment Type
Contract
