SeniorPrincipal Scientist Systems Pharmacology PBPK DDI mfd
SeniorPrincipal Scientist Systems Pharmacology PBPK DDI mfd
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1 Vacancy
Job Description
Are you a talented and motivated lifescience modelling & simulation scientist with experience in the pharma industry Do you enjoy driving innovation and setting new boundaries in physiologicallybased (PBPK/DDI) modelling This position offers you this and more exciting work in an innovative and fastpaced environment.
ESQlabsis an innovative internationally acting Contract Research Organization and a global leader in the development and application of the OSP Suite (). We are a researchfocused provider of specialized computational analyses in the life sciences industry.
To help us grow our global PBPK/DDI impact we are looking for a Senior/Principal Scientist Systems Pharmacology PBPK / DDI to strengthen our multidisciplinary project teams for the successful completion of client goals.
Role
- Complement a dedicated highperforming team of scientists
- Collaborate with colleagues on multidisciplinary teams to implement quantitative clinical pharmacology projects/programs and to provide clinical pharmacology and PBPK/DDI consultation to other company projects/programs
- Provide clinical pharmacology and pharmacometric consulting through advanced PBPK/DDI and exposureresponse modeling and simulation using the OSPSuite (PKSim MoBi R) or other tools
- Support clinical pharmacologyrelated components of clinical study protocols study conduct data analysis and report writing with the support of colleagues
- Responsible for appropriateness of methods integrity of data used for analysis and accuracy of results
- Regularly engage with clients regarding the strategic approach project executionpresentation of results regulatory implications and messaging of findings
- Prepare final technical reports synopses executive summaries and other regulatory documents
- Ensure the provision of advanced literature searches for project/programrelated information
- Provide sophisticated written interpretation of material and integrate research findings into project/program methodology and results
- Share findings with internal and external project teams;prepare abstracts presentations and publicationready manuscripts
- Provide mentoring and feedback to junior scientists
- Integrate knowledge of PBPK and DDI to provide guidance regarding proposed approaches to addressing drug development and regulatory approval challenges
- Expand scientific expertise through attendance and presentation at international national and regional scientific conferences client meetings and government meetings
- Develop and teach at OSPSuite (PKSim MoBi R) and other workshops and courses
Required skills & experience
- 5 years (Principal 10 years)of applied (pre)clinical pharmacology experience
- 3 years (Principal 5 years)of leading projects and programs
- 3 years (Principal 5 years)of experience in regulatory applications of PBPK modeling in preclinical and clinical development
- Good knowledge of regulatory requirements and guidelines for PBPK and DDI
- Strong experience presenting scientific results to professional audiences
- Extensive experience preparing submitting and receiving approval for publications in scientific journals
- Mechanistic physiologically based pharmacokinetic modeling and simulation experience
- Expert knowledge in domainspecific modeling software (e.g. PKSim /MoBi SimCyp or GastroPlus)
- Excellent communication presentation and leadership skills
- Relationshipbuilding skills with the ability to work closely with project leaders and team members
- Strong organization skills and ability to handle multiple tasks simultaneously
- Work well handling tight deadlines
- Great criticalthinking and problemsolving skills
- Fluency in English (oral and written) German is a plus
Education
- PhD or masters in quantitative sciences (Bioengineering Applied Math ...) with advanced (pre)clinical pharmacology related training or
- PharmD or PhD in pharmacokinetics clinical pharmacology or related field with advanced applied mathematics related training
Further qualities that will put you in the spotlight
- Experience in (IND/NDA)submissions
- Advanced expertise in pharmacometric modeling software (e.g. NONMEMMonolix or IQRtools)
- Proficiency in a scripting language for modeling and simulation (ideally R alternatively MATLAB)
- A strong understanding of statistics
- Therapeutic domain knowledge: Diabetes Oncology Immunology or Inflammation
- Published peerreviewed articles
Whats in store for you
The dynamic team behind ESQlabs unites people with different backgrounds spanning disciplines like pharmaceutical sciences physics bioinformatics mathematics data science and software engineering. Our trust in each other our openmindedness and our constant quest for excellence and innovation unite us. We value flat hierarchies where everyone can contribute ideas and expertise to develop the best product. We are passionate always willing to broaden our horizons and love our startup culture.
You will also benefit from:
- Flexible work hours and a home office policy that focuses on people and not on numbers
- An attractive remuneration package
- A dedicated budget for education programs and conferences you can attend
- A working environment in which your contribution will make a difference and that allows you to take ownership of projects and processes
- Responsibility autonomy participation and career perspective
About us
We collaborate with global corporations in the pharma and chemical industry as well as startups in the lifescience technology sector and academic and nonprofit research institutions. We define new standards in pharmacometrics and systems pharmacology and toxicology areas. Our software and model platforms help scientists understand mechanisms of diseases and chemical toxicity to optimize individualized treatment of patients and protect the health of the animal and human life.
ESQlabshas attracted international players as sponsors for the OSP Software development. In addition funding through national and EUwide research grants allows us to develop our core technologies continuously.
For more information about our culture values and benefits visit ourUnique career opportunities ESQlabsGmbH.
At ESQlabs we are committed to diverse backgrounds and experiences.
Employment Type
Full Time
Company Industry
Key Skills
- Machine Learning
- Python
- Data Science
- AI
- R
- Research Experience
- Sensors
- Drug Discovery
- Research & Development
- Natural Language Processing
- Data Analysis Skills
- Toxicology Experience
