Postdoctoral position in Bio-Informatics to unravel the metastatic journey in time and space
Postdoctoral position in Bio-Informatics to unravel the metastatic journey in time and space
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Job Description
When cancer cells leave the primary tumor to seed in other organs they need to seek the help of different cell types in distinct environments to make their journey successful. Lymph nodes (LN) which counterintuitively are centers for Tcellantigen priming are the first metastatic relay before cancer cells disseminate to distant organs. Thereby tumoremanating signals can create a premetastatic niche in sentinel LN that renders T cells nonresponsive to arriving tumor cells. However the mechanistic underpinnings of how tumor cells induce a premetastatic niche in LNs escape cell death and immunosurveillance upon seeding in the LN and leave to settle in the lung and other organs are less understood. The overarching goal of our project is to provide a first holistic view of the spatial and temporal 4D changes of the vascular immune and stromal components in the LNs from homeostasis to the metastatic state through stateoftheart approaches (4D intravital imaging singlecell/spatial transcriptional spatial proteomic and metabolic profiling) of murine and human metastatic cancers.
Are you curious about the mechanistic underpinnings of metastatic spread and can you use your strong bioinformatics expertise and knowledge in programming languages and transcriptomic/multiomic data analysis to help us unravel the complex interaction of cancer cells and their environments to enable metastatic spread Are you driven to establish your research project and enjoy working with a multidisciplinary team in a dynamic stimulating working environment and close collaboration with clinical and industrial partners
You will work with the teams of Prof. Colinda Scheele and Prof. Gabriele Bergers at the VIB branch Center for Cancer Biology (CCB) at KU Leuven/Campus Gasthuisberg in Leuven (Belgium). The VIB is a top research institute for life sciences. The VIBCCB entails 12 leading research groups in (immuno)oncology the tumor microenvironment genetics/multiomics molecular biology and translational research with core facilities and excellence centers that are wellequipped with the newest stateoftheart technologies relating to single cell/spatial transcriptomics metabolomics FACS and multiplex profiling. In addition VIB recently established an artificial intelligence (AI) center which will further foster interactions and collaborations relating to computational projects within the different VIB centers.
You can find more information about our center and our teams here:
How to apply
If you want to make the journey with us to unravel metastatic spread in time and space please complete the online application procedure () and include:
- A detailed CV including a list of your scientific publications
- A detailed cover letter describing your motivation
- The contact information of 3 referees
Application deadline: December 15 2024.
Employment Type
Full Time
