Post-doc Cellular biology of heterotypic amyloid interactions

We are looking for a highly skilled postdoctoral researcher with strong expertise in cell biology to join our NIHfunded project which focuses on identifying and characterizing heterotypic amyloid interactions as modulators of selective cellular vulnerability. As the project progresses we are entering a crucial phase that involves detailed cellular assays to explore and validate the roles of these interactions. Your expertise will be key in driving this exciting research forward and exploring the implications of these interactions in cellular systems.

What is the project all about

Amyloid aggregates manifest in specific brain regions while sparing others. Our project aims to unravel whether heterotypic interactions between aggregationprone regions of amyloidforming proteins and the background proteome dictate this selective vulnerability. This hypothesis will be tested using a genomewide computational screen followed by experimental validation in cellular models and subsequently in mice. A key aspect of this research will involve cell biological techniques to validate interactions and elucidate how these alter cellular functions and drive disease processes.

About the lab

The SWITCH Laboratory is a leading research group focused on the cell biology and biophysics of protein aggregation in human disease. Our interdisciplinary team of over twentyfive researchers including experts in cell biology bioinformatics biophysics and chemistry provides a rich environment for cuttingedge research. We are equipped with stateoftheart facilities for cellular and molecular biology including advanced microscopy highcontent screening and other tools essential for cell biology research. You can read more about us on our website and be sure to check out our laboratory section to explore the fantastic infrastructure that SWITCH has to offer!

Your Job

As a key member of our heterotypics team you will be at the forefront of this project integrating your expertise in cellular biology with protein aggregation research. Working closely with the PIs of the Switch Lab this role offers a mix of handson experimental work and data analysis with robust administrative support to ensure you can focus on driving scientific discovery.

Your profile

• PhD with strong focus on Cell Biology ideally in the setting of protein aggregation protein homeostasis or a related field.
• Extensive experience with cellular models and assays related to protein aggregation including microscopy cellbased screening and related techniques.
• A solid publication record including firstauthor research articles in peerreviewed international journals.
• A strong interest in understanding the cellular mechanisms underlying protein aggregation and its implications in disease.
• Highly motivated enthusiastic and innovative with excellent communication skills.
• Ability to work effectively in a multidisciplinary team.
• Prior experience in project coordination or supervision is a plus.

We offer

• A vibrant worldclass research environment operating at an international level
• Access to the resources of two host institutions:
  • VIB an excellencebased research institute
  • KU Leuven one of Europes leading research universities

• Stateoftheart research facilities.
• A dedicated training program to broaden your expertise and enhance your skill set.
  At SWITCH we pay particular attention to the career development goals of our people and actively support the ambitions of our lab members in the lab and beyond. Information on SWITCH Lab alumni can be found here.
• A competitive compensation package based on expertise and experience

Starting Date: as soon as possible

How to apply

For more information contact Please complete the online application procedure and include a detailed CV including list of publications a motivation letter and the contact information of at least two referees.