Scientist - III Senior - MA Only

Job Title: Scientist III (Senior)

Duration: 24 Months (Contract)

Shift: Mon Fri 8AM5PM

Location: Cambridge MA 02141

Responsibilities:

Scientist invitro disease modeling

Clients Sciences department in MRL is looking for a motivated scientist to lead the identification and validation of new genetic targets for various cardiometabolic diseases including Type 2 Diabetes (T2D) Obesity Atherosclerosis Retinal diseases and vascular diseases. This individual will play a pivotal role as a member of the discovery team contributing to the development of innovative models for screening drug targets.

Job responsibilities:

• Establish stem cellbased invitro disease platforms.
• Design assays using high content imaging techniques to facilitate screening of small molecules and genetic modifications using CRISPR.
• Perform lab experiments interpret data and effectively communicate findings.
• Collaborate with crossfunctional teams in therapeutic and functional areas.
• Maintain electronic lab notebook and sample inventories.

Education requirements:

• BS with 5 years of experience/Masters with 3 years of experience/PHD with 1 year of experience in a wet lab setting.
• Candidates with a background in muscle biology will be given preference.

Required experience and skills:

• Skilled in cell culturing and differentiation of stem cells into specific lineages.
• Experience with gene manipulation technologies such as CRISPR siRNA ASOs lentivirus and AAVs.
• Expertise in molecular biology techniques including RNA extraction qPCR ELISA/MSD and ICC.
• Critical thinking with an ability to formulate experimental strategies.
• Effective in working independently and collaboratively within a team.
• Outstanding verbal and written communication skills.