Formulation Senior Scientist Tumour Targeted Delivery Oncology RD

About AstraZeneca

AstraZeneca is a global scienceled patientfocused biopharmaceutical company that focuses on the discovery development and commercialisation of prescription medicines for some of the worlds most serious diseases. But were more than one of the worlds leading pharmaceutical companies.

Site description

Our TTDChemistry site situated in Whitechapel London is one of over 400 sites here at AstraZeneca providing an environment where everyone feels comfortable and able to be themselves is at the core of AstraZenecas priorities its important to us that you bring your full self to work every day. To help you maintain your best self heres a sneak peek into some of the things this site provides for you Afterwork events Lunch Learns spacious balanced office working environment. Situated in the heart of Londons historical east end close to the fashionable areas of Shoreditch Spitalfields and Brick Lane with excellent public transport links to central London.

Business area

Take our leading Oncology pipeline to the next level! Working with one of the broadest and deepest Oncology pipelines in the industry offers the possibility to work on the most novel molecules at all development stages. It takes each of us challenging our thinking to keep pushing our pipeline forward and craft the future of Oncology. Inperson working gives us the platform we need to connect work at pace and challenge perceptions. Thats why we work on average a minimum of three days per week from the office.

What youll do

• As a Formulation Senior Scientist you will use your scientific judgement to develop colloidally and conformationally stable formulations of conjugated biologics.
• You will perform biophysical characterisation and associated stability studies analyse and interpret experimental data and contribute to decision making for earlystage drug discovery programmes.

Essential for the role

• Ph.D in Chemistry Biochemistry Bio/Chemical engineering Pharmaceutical Sciences or relevant discipline
• M.Sc or B.Sc in above disciplines with relevant industrial experience
• Experience with formulation strategies purification biophysical characterization and stability testing of proteins/conjugates
• Knowledge of antibody and/or general protein sequence and structural analysis
• Strong background in chemistry and protein biochemistry
• Hands on experience of performing a range of protein/bioconjugate characterisation by Dynamic Light Scattering (DLS) Differential Scanning Calorimetry (DSC) sizeexclusion/hydrophobic interaction/ion exchange chromatography HPLC cIEF ceSDS nephelometry UV/Vis spectroscopy and LCMS
• Experience with executing preparative chromatography purifications using AKTA and TFF systems
• Knowledge and strong understanding of developing and optimising robust analytical methods for antibody drug conjugate/protein related conjugates characterisation might be beneficial.

Please use the below link for job application and quicker response.

Remote Work :

No