Computational Biologist Principal Scientist

Career Category

Job Description

Join Amgens Mission of Serving Patients

At Amgen if you feel like youre part of something bigger its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.

Since 1980 weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology Inflammation General Medicine and Rare Disease we reach millions of patients each year. As a member of the Amgen team youll help make a lasting impact on the lives of patients as we research manufacture and deliver innovative medicines to help people live longer fuller happier lives.

Our awardwinning culture is collaborative innovative and science based. If you have a passion for challenges and the opportunities that lay within them youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Computational Biologist

What you will do

Lets do this. Lets change the world. The Computational Biology group in the Center for Technology and Innovation (CfTI) within the Precision Medicine organization at Amgen is seeking a highly motivated Computational Biologist with expertise in analyzing clinical biomarker data including but not limited to genomics transcriptomics proteomics spatialomics flow cytometry immunoassays and other biomarker assays. In this vital role you will contribute to advancing Amgens clinical programs and studies by integrating computational biology and bioinformatics techniques with biological and clinical data. The ideal candidate will have experience in matrixed environments supporting therapeutic development by providing insights derived from clinical biomarker data. A background in inflammation and immunology rare diseases or cardiometabolic disease is preferred to support key areas of Amgens therapeutic focus.

• Support Amgen program/portfolio teams as a biomarker analysis lead.

• Development of biomarker analysis plans to support precision medicine evidence generation and reverse translation during clinical development of therapeutic molecules.

• Design and execute workflows for biomarker data analysis integrating genomics transcriptomics proteomics imaging and biomarker measure using other assays/platforms to support Amgens early and late clinical development programs.

• Lead the analysis and interpretation of clinical biomarker data from various assay platforms including imaging flow cytometry immunoassays transcriptomics proteomics and spatialomics etc.

• Design and implement computational algorithms to analyze multiomics multimodal and highcontent data with applications in target engagement evaluation patient stratification response prediction indication selection assay development and diagnostic development.

• Work closely with clinical scientists and biomarker leads to extract biological insights from highdimensional datasets and integrate them into reverse translational research and clinical development plans.

• Collaborate crossfunctionally with early development teams biostatistics clinical pharmacology clinical biomarker leads and research teams to manage data integration analysis and presentation.

What we expect of you

We are all different yet we all use our unique contributions to serve patients. The dynamic professional we seek is a leader with these qualifications.

Basic Qualifications:

• Doctorate degree and 2 years of scientific experience

Or

• Masters degree and 5 years of scientific experience

Or

• Bachelors degree and 7 years of scientific experience

Preferred Qualifications:

• PhD in Bioinformatics Mathematics Computer Science Computational Biology or Data Science with a minor or robust background in Biology

• Handson experience in statistical modeling machine learning and AI applied to clinical biomarker and clinical efficacy data.

• A strong understanding and practical skills in statistics and their use in data analysis for clinical settings

• Proven expertise in analyzing multimodal multidimensional and largescale biological data.

• Prior experience working in a matrixed biotechnology or pharmaceutical setting.

• Proficiency in R and Python programming with familiarity in various principles for data manipulation and visualization.

• Strong understanding of platforms used in clinical biomarker research including flow cytometry immunoassays nextgeneration sequencing (NGS) and proteomics.

• Knowledge of immunology autoimmune diseases cardiometabolic disease or oncology and how computational biology can drive drug discovery and development in these areas.

• Ability to translate biological and medical questions into analytical models providing actionable results

• Excellent written and oral communication skills with the ability to present complex data analyses in diverse settings including crossfunctional team meetings external collaborations and scientific publications.

• Strong project management skills and organizational awareness selfmotivation independence and leadership

What you can expect of us

As we work to develop treatments that take care of others we also work to care for your professional and personal growth and wellbeing. From our competitive benefits to our collaborative culture well support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to relevant skills experience and qualifications.

In addition to the base salary Amgen offers a Total Rewards Plan based on eligibility comprising of health and welfare plans for staff and eligible dependents financial plans with opportunities to save towards retirement or other goals work/life balance and career development opportunities that may include:

• A comprehensive employee benefits package including a Retirement and Savings Plan with generous company contributions group medical dental and vision coverage life and disability insurance and flexible spending accounts

• A discretionary annual bonus program or for field sales representatives a salesbased incentive plan

• Stockbased longterm incentives

• Awardwinning timeoff plans

• Flexible work models including remote and hybrid work arrangements where possible

Apply now

for a career that defies imagination

Objects in your future are closer than they appear. Join us.

careers.amgen

In any materials you submit you may redact or remove ageidentifying information such as age date of birth or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

As an organization dedicated to improving the quality of life for people around the world Amgen fosters an inclusive environment of diverse ethical committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race color religion sex sexual orientation gender identity national origin protected veteran status disability status or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process to perform essential job functions and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Salary Range