Associate Scientist or Lead Researcher - Protein Engineering and Design Genome Editing Biotechnology Shengdar Q Tsai Lab
Associate Scientist or Lead Researcher - Protein Engineering and Design Genome Editing Biotechnology Shengdar Q Tsai Lab
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$ 65520 - 114400
1 Vacancy
Job Description
Overview of our lab:
The Tsai lab is a highly collaborative creative and fun group of scientists at St. Jude Childrens Research Hospital. Our research program centers on dethe development of stateoftheart genomic methods for understanding the global activities of genome editors protein engineering to improve their capabilities for precise editing and translation to autologous genomeeditedematopoietic stem cell therapies.
About the job opportunity:
We are seeking an outstanding and highly motivated Lead Researcher to help lead efforts to develop personalized genome editing treatments. We care deeply about the success of our scientists and this job is a unique opportunity to learn about genomics genome editing and protein engineering while contributing to the development of future individualized genomic medicines at St. Jude with room for career growth and advancement.
Dr. Tsai is coleading a new Blue Sky Project called PARADIGM (Partnership to Advance Development of Individualized Genomic Medicines) with the goal of developing personalized genome editing therapies for St. Jude patients.
You would have opportunities to lead exciting projects that include:
Protein engineering of improved novel CRISPR base and prime genome editors with human cellbased directed evolution.
Develop scalable methods to characterize large numbers of CRISPR genome editing variants for activity and specificity with massively parallel highthroughput sequencing approaches.
Design and test new CRISPR genome editors with generative artificial intelligence protein large language models.
Help develop laboratory automation workflows to perform scalable protein engineering.
Understanding the structurefunction relationship of mutations identified from highthroughput screens on the activity of genome editors.
Perform deep mutational scanning of CRISPRCas orthologues and effector domains important for precise genome editing such as deaminases and reverse transcriptases.
Define the outcome of engineered variants on genome editing repair outcomes using highthroughput genomic methods.
You would learn valuable laboratory skills that include:
Genome engineering highthroughput genomics nextgeneration sequencing protein engineering structural biology liquid handling automation hematopoietic stem cell culture and transfection and data science.
Projectdependent responsibilities could include:
Engineer CRISPR base and prime editors with improved activity and specificities.
Optimize lead protein candidates by structureguided design and highthroughput screening.
Apply new artificial intelligence and machine learning techniques to guide protein engineering design.
Analyze experimental outcomes and develop highquality summaries towards manuscripts and grant applications.
Draft manuscripts and figures for publication in highimpact journals.
Other Job Responsibilities:
Independently perform experiments using existing modified or newly developed techniques/ protocols.
Set up protocols using new or modified laboratory techniques and troubleshoot experiments independently.
Identify experimental data pertinent to the analysis problem; process organize and summarize data; report results.
Maintain uptodate knowledge of the field and related techniques.
Provide ongoing support for monitoring maintenance ordering and purchasing of equipment and supplies as needed.
Provide guidance and training to lessexperienced team members and may also train others outside lab in relevant techniques.
Perform other duties as assigned to meet the goals and objectives of the department and the institution.
Maintain regular and predictable attendance.
Minimum Education and/or Training:
Bachelors degree in a relevant scientific area
Associate Scientist Minimum Experience:
7 years of research experience is required
5 years of research experience is required with a Masters degree
2 years of research experience is required with a PHD
Experience leading and supporting research experiments preferred
Some experience leading lab and scientific project coordination maintenance and other research support activities preferred
Experience in guiding and training other laboratory personnel preferred
Proven performance in earlier role/comparable role
Lead Researcher Minimum Experience:
Five 5 years of relevant postdegree work experience is required
Two 2 years of relevant postdegree work experience is required with a Masters degree
No experience is required with a PHD
Compensation
In recognition of certain U.S. state and municipal pay transparency laws St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets experience and training licensure and certifications and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $65520 $114400 per year for the role of Associate Scientist or Lead Researcher (Protein Engineering and Design Genome Editing Biotechnology Shengdar Q. Tsai Lab).Explore our exceptional benefits!
No Search Firms
St. Jude Childrens Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.
Required Experience:
IC
Employment Type
Full-Time
