Senior Scientist I Biologics Discovery Sciences
Senior Scientist I Biologics Discovery Sciences
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1 Vacancy
Job Description
We are seeking a highly motivated Research Scientist to join AbbVies dynamic core team within the Discovery Research function. As part of the Biotherapeutic Discovery Production group you will contribute significantly to advancing biologics drug discovery through your expertise in protein analytics characterization engineering and production.
This role emphasizes the thorough characterization of bispecific modalities using protein and peptide mass spectrometry. Your objective will be to fully characterize lead and candidate molecules identify molecular liabilities and advance the most promising candidates. You will not only conduct detailed analyses of final purified molecules but also support the characterization of process intermediates identifying productrelated impurities and modified forms to aid in the development of effective purification processes.
The ideal candidate will possess extensive expertise in protein mass spectrometry and a deep understanding of identifying posttranslational modifications and disulfide bond structures of biologic molecules. This includes confirming the correct assembly of multispecific molecules. Additionally you will play a crucial role in developing and implementing new technologies and platforms to enhance the efficiency of the drugdiscovery process for multispecific therapeutic proteins particularly at the intersection of bispecific modalities and the application of LCMS for product verification.
This position is located at our headquarters in North Chicago IL.
Key Responsibilities:
- Identify develop and implement new technologies/platforms that improve the efficiency of the overall drugdiscovery process for multispecific therapeutic proteins especially as related to the intersection of bispecific modalities and the use of LCMS to confirm the identity of correctly assembled products.
- Maintain a high level of productivity in the lab conducting research independently and managing several projects simultaneously. Autonomously design execute and interpret experimental results.
- Optimize workflows to address evolving timelines and priorities by integrating automation into platform methods.
- Contribute to project teams and work effectively across functional groups to help advance programs.
- Stay current with applicable internal/external scientific literature and apply new information in innovative ways to successfully complete work assignments.
- Routinely demonstrate scientific initiative and creativity in research activities.
- Demonstrates high proficiency across a wide range of relevant technologies.
- Analyze document and report data concisely and rigorously.
Qualifications :
Qualifications:
- Bachelors Masters or Ph.D. degree in Biochemistry Biophysics Analytical Chemistry or a related field.
- Experience requirements vary based on educational level:
- For Ph.D. holders: Typically 04 years of experience.
- For Masters degree holders: Typically 810 years of experience.
- For Bachelors degree holders: Typically 1012 years of experience.
- Demonstrated skill in identification and mapping of liabilities/PTMs in Biologic Drug Candidate molecules is a must.
- Must be proficient in liquid chromatography and mass spectrometry analysis of novel Biotherapeutics especially as relates to correct disulfide structure and pairing of chains in multispecific modalities.
- Ability to deliver near realtime analytical results in order to guide the biotherapeutic candidate production process path is required.
- Deep understanding of Protein Metrics and Mass Hunter analysis software is a plus.
- Demonstrated ability to oversee maintain and troubleshoot liquid chromatography and mass spectrometry instrumentation.
- Should possess excellent communication skills and be proficient in presenting in front of groups.
Additional Information :
Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location and we may ultimately pay more or less than the posted range. This range may be modified in the future.
We offer a comprehensive package of benefits including paid time off (vacation holidays sick) medical/dental/vision insurance and 401(k) to eligible employees.
This job is eligible to participate in our shortterm incentive programs.
Note: No amount of pay is considered to be wages or compensation until such amount is earned vested and determinable. The amount and availability of any bonus commission incentive benefits or any other form of compensation and benefits that are allocable to a particular employee remains in the Companys sole and absolute discretion unless and until paid and may be modified at the Companys sole and absolute discretion consistent with applicable law.
AbbVie is an equal opportunity employer and is committed to operating with integrity driving innovation transforming lives serving our community and embracing diversity and inclusion. It is AbbVies policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race color religion national origin age sex (including pregnancy) physical or mental disability medical condition genetic information gender identity or expression sexual orientation marital status status as a protected veteran or any other legally protected group status.
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Remote Work :
No
Employment Type :
Fulltime
Employment Type
Full-time
