Senior Scientist I Computational Chemistry
Senior Scientist I Computational Chemistry
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Salary Not Disclosed
1 Vacancy
Job Description
Organization Overview
The Molecular Profiling and Drug Delivery (MPDD) function within the Small Molecule CMC organization is accountable for a broad range of deliverables across various stages of drug discovery and development. During lead generation/optimization and through candidate selection MPDD scientists utilize state of the art automation and computational tools supported by expertise in biopharmaceutics drug delivery and solidstate chemistry to collaboratively progress candidates with higher probability of success into development and advise clinical formulation strategy. From candidate selection through clinical proof of concept and product launch MPDD scientists work in cross functional teams to identify the commercial solid form of the active pharmaceutical ingredient (API) and establish structurepropertyperformance correlations to help deliver robust commercial processes and align control strategies across drug substance and product. They also transition drug substance isolation processes and relevant physical characterization methods to commercial manufacturing sites and work within teams to ensure successful regulatory submissions.
Computational chemists within AbbVies MPPD organization work collaboratively with other functions within Development Sciences and Discovery Sciences across four focus areas: molecular design materials profiling formulation design and compound profiling (large and small molecules) towards the vision of guiding the design and progression of compounds with optimal developability properties and impacting project team decisions. Computational chemists focus on developing a hierarchical modeling approaches including physicsbased atomistic modeling encompassing Molecular Dynamics (MD) and Quantum Mechanics (QM) Machine learning (ML)/Artificial Intelligence (AI) and hybrid models based on PhysicsML/AI approaches. Computational chemists also collaborate seamlessly with medicinal chemists data scientists material scientists and molecular modelers to incorporate these models in project screening funnels and medicinal chemistry design cycle.
Position Overview
AbbVies MPDD organization is seeking a highly motivated talented and creative scientist with experience and expertise in computational chemistry for a Senior Scientist position. This person will make key contributions towards enablement of our modeling vision. Specifically the person will be working collaboratively with discovery colleagues to develop stageappropriate computational models using advanced computational techniques to enable design and optimization of drug candidates. The ideal candidate should possess an advanced degree in computational chemistry with a strong background in the area such as quantum mechanics atomistic molecular simulations (molecular dynamics) and AI/machine learning.
Responsibilities
- Build computational models for a variety of applications to enable the design and optimization of drug candidates for clinical advancement. Examples include but are not limited to utilization of molecular simulation/QM approaches to predict aqueous/organic solubilities chemical stabilities crystal structures and dynamics of small molecules and proteins binding affinities of ligands permeability and conformations of molecules.
- Serve as a lead computational scientist on project teams and drive the development and implementation of appropriate computational models within projects to support various aspects of drug discovery and drug development.
- Generate hypotheses for compound property improvement and apply them to new compound designs
- Advance our computational chemistry capabilities through innovation and implementation of new methodologies and workflows
- Contribute to the development of computational infrastructure by identification of novel tools and techniques
- Play a strong team player in a cross functional collaborative environment
- Demonstrate excellent communication skills and specifically
- Illustrate strong oral and written technical communications
- Promote designdriven and predictfirst culture
- Educate and train colleagues on various computational tools and techniques
Qualifications :
- Bachelors Masters or PhD with 8 (BS) 5 (MS) and 03 (PhD) years of experience in computational chemistry computer science biophysics chemical engineering or related field
- Knowledge in one or more areas of the computational chemistry discipline such as quantum mechanics molecular dynamics structurebased design ligandbased design structure property relationship modeling physicochemical property prediction
- Advanced user of QM or MD software packages. This may include opensource codes (GROMACS OpenMM LAMMPS) or commercial software (Schrodinger OpenEye MOE etc).
- Ability to build and integrate computational models through combining different workflows while also modifying or improving workflow source codes as needed.
- Familiarity with machine learning or neural network packages including but not limited to Scikitlearn Pytorch
- Well versed in writing codes in Python Jupiter R C/C etc.
Key Competencies
- Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance.
- Learns fast grasps the essence and can change course quickly where indicated.
- Raises the bar and is never satisfied with the status quo.
- Creates a learning environment open to suggestions and experimentation for improvement.
- Embraces the ideas of others nurtures innovation and manages innovation to reality
Additional Information :
- Location: ABC Site Worcester MA. Potential for hybrid flexibility with majority of time spent being onsite.
- The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location and we may ultimately pay more or less than the posted range. This range may be modified in the future.
- We offer a comprehensive package of benefits including paid time off (vacation holidays sick) medical/dental/vision insurance and 401(k) to eligible employees.
- This job is eligible to participate in our shortterm incentive programs.
Note: No amount of pay is considered to be wages or compensation until such amount is earned vested and determinable. The amount and availability of any bonus commission incentive benefits or any other form of compensation and benefits that are allocable to a particular employee remains in the Companys sole and absolute discretion unless and until paid and may be modified at the Companys sole and absolute discretion consistent with applicable law.
AbbVie is an equal opportunity employer and is committed to operating with integrity driving innovation transforming lives serving our community and embracing diversity and inclusion. It is AbbVies policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race color religion national origin age sex (including pregnancy) physical or mental disability medical condition genetic information gender identity or expression sexual orientation marital status status as a protected veteran or any other legally protected group status.
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Remote Work :
No
Employment Type :
Fulltime
Employment Type
Full-time
