Scientist l LBA Operations
Scientist l LBA Operations
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Salary Not Disclosed
1 Vacancy
Job Description
Purpose
We are seeking an independent knowledgeable and highly motivated Ligand Binding Assay Scientist (Scientist I) to join the Quantitative Translational and ADME Sciences (QTAS) department at Abbvie Bioresearch Center in Worcester MA.
The LBA Operations Bioanalytical team at ABC QTAS conducts nonregulated preclinical quantitative bioanalysis assays of large molecule therapeutics like monoclonal antibodies (mAb) bispecific Ab antibodydrug conjugates (ADC) and fusion protein for Pharmacokinetic (PK) Pharmacodynamic (PD) and Toxicokinetic (TK) studies using ligand binding assays to support early development and drug discovery efforts.
As a Scientist I you will be responsible for: 1) Conducting assay development and preclinical sample analysis using ligand binding assay and automated liquid handlers 2) Sample protocol and reagent management using electronic tools such as Laboratory Information Management System (rLIMS) and enotebooks 3) Reporting discussing and QCing results to project teams which enable pharmacokinetic and pharmacodynamic analysis in support of oncology immunology neurology and other AbbVie therapeutic portfolios.
Responsibilities
- Develop and qualify ligand binding assays (PK PD ADA) using Meso Scale Discovery platform and colorimetric ELISA or other assay platforms.
- Plan and execute sample analysis based on bioanalytical protocol and in vivo study design on a variety of biological matrices (tissue lysates serum others).
- Analyze preclinical in vivo samples based on dynamically changing operational schedule.
- Interpret present and discuss assay results. Make decision on assay readiness for preclinical support and dosing regimen decisions.
- Data archiving in ELN and rLIMS.
- Effectively communicate experimental plan and results verbally and in writing with broader teams.
- Actively support lab team daytoday lab operations.
- Write and update experimental protocols and procedures.
- Initiate design interpret troubleshoot operational assays independently and efficiently.
Qualifications :
- Bachelors degree in biology biochemistry pharmacology or related field with at least 5 years of pharmaceutical experience or MS in mentioned fields with 2 years of relevant experience.
- Attention to detail experience in performing bioanalysis being independent and a selfmotivated contributor.
- Ability to operate and maintain laboratory equipment and reagents/material inventories independently.
- Experience with lab automation is desirable.
- Experience with ligand binding workflow and assay development and troubleshooting is required.
- Proven independence and problemsolving ability.
- Excellent written and verbal communication skills and ability to draft technical reports.
- Proficiency with computers and data analysis software including Excel and LIMS
- Ability to summarize communicate and interpret bioanalytical results.
- Work effectively in a highly collaborative and multidisciplinary environment.
Additional Information :
Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location and we may ultimately pay more or less than the posted range. This range may be modified in the future.
We offer a comprehensive package of benefits including paid time off (vacation holidays sick) medical/dental/vision insurance and 401(k) to eligible employees.
This job is eligible to participate in our shortterm incentive programs.
Note: No amount of pay is considered to be wages or compensation until such amount is earned vested and determinable. The amount and availability of any bonus commission incentive benefits or any other form of compensation and benefits that are allocable to a particular employee remains in the Companys sole and absolute discretion unless and until paid and may be modified at the Companys sole and absolute discretion consistent with applicable law.
AbbVie is an equal opportunity employer and is committed to operating with integrity driving innovation transforming lives serving our community and embracing diversity and inclusion. It is AbbVies policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race color religion national origin age sex (including pregnancy) physical or mental disability medical condition genetic information gender identity or expression sexual orientation marital status status as a protected veteran or any other legally protected group status.
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Remote Work :
No
Employment Type :
Fulltime
Employment Type
Full-time
