Co-op Gene Therapy Immunogenicity
Co-op Gene Therapy Immunogenicity
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Job Description
This application is for a 6month student role from July December 2025. Resume review begins in January 2025.
The Gene Therapy Accelerator Unit (GTxAU)s remit is to develop safe and efficacious gene therapies for patients with neurological and rare diseases. The Performance team within GTxAU supports this mission by evaluating viral and nonviral gene therapy attributes their performance in vivo (biodistribution expression) and immune responses following administration of gene therapies. Furthermore we are focused on limiting undesirable immune responses to gene therapies to improve the safety and performance of gene therapies in the clinic.
Position Description
In this position you will partner with project teams to define scientific questions to generate testable immunogenicity mitigation strategies. Youll be responsible for designing executing and interpreting in vitro and in vivo experiments. You will record all protocols data and conclusions in your electronic laboratory notebook and present results at internal meetings.
Example projects may include:
- Evaluation of plasmacytoid dendritic cells role in CD8 T cell responses to AAV capsid
- In vivo testing of pharmacologic agents to prevent de novo antibody responses to AAV capsid
- Establish in vitro assays to interrogate innate immune responses to various LNPmRNA gene therapies
Qualifications :
- Proficient in molecular and cell biology techniques (DNA/RNA extraction cell culture and aseptic technique ELISAs and western blotting)
- In vivo experience with basic rodent handling and tissue collection and processing
- Experienced in flow cytometry
- Strong critical thinking organization and communication skills
To participate in the Biogen Internship Program students must meet the following eligibility criteria:
- Legal authorization to work in the U.S.
- At least 18 years of age prior to the scheduled start date
- Be currently enrolled in an accredited community college college or university with a graduation date no earlier than December 2025.
Education
- B.S. in Biology or Life Sciences related majors. Currently enrolled in a M.S. or Ph.D. program preference for those with a focus in Immunology or Neuroimmunology.
Location
- This position is onsite in Cambridge MA.
Additional Information :
Why Biogen
We are a global team with a commitment to excellence and a pioneering spirit. As a midsized biotechnology company we provide the stability and resources of a wellestablished business while fostering an environment where individual contributions make a significant impact. Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning growth and expanding their skills. Above all we work together to deliver lifechanging medicines with every role playing a vital part in our mission. Caring Deeply. Achieving Excellence. Changing Lives.
At Biogen we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds cultures and perspectives make us a stronger and more innovative company and we are focused on building teams where every employee feels empowered and inspired. Read on to learn more about our DE&I efforts.
All qualified applicants will receive consideration for employment without regard to sex gender identity or expression sexual orientation marital status race color national origin ancestry ethnicity religion age veteran status disability genetic information or any other basis protected by federal state or local law. Biogen is an EVerify Employer in the United States.
Remote Work :
No
Employment Type :
Fulltime
Employment Type
Full-time
