Postdoctoral researcher to develop antisense therapies for familial Alzheimers Disease
Postdoctoral researcher to develop antisense therapies for familial Alzheimers Disease
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Job Description
Description
The Laboratory for the Research of Neurodegenerative Diseases headed by prof. Bart De Strooper in collaboration with the Laboratory for Therapeutic and Diagnostic Antibodies headed by Prof. Maarten Dewilde is looking for a motivated postdoctoral scientist to join our multidisciplinary project on gene therapy for Alzheimers Disease.
This work is focused on the specific targeting of clinical mutations that cause dominant inherited Alzheimers disease using a unique antisense strategy (ASO). We will couple those ASO to our proprietary bloodbrain shuttles to improve brain exposure improve administration via intravenous instead of intrathecal routes and decrease toxicity associated with ASO treatment.
The candidate will be involved in both the generation and the testing of the ASO constructs and will follow the clinical candidates on their journey from preclinical to clinical application.
Additional information may be found in the following selected references:
- De Strooper B. & Karran E. New precision medicine avenues to the prevention of Alzheimers disease from insights into the structure and function of gammasecretases. EMBO J(2024).
- Rue L. et al. Novel Human/NonHuman Primate CrossReactive AntiTransferrin Receptor Nanobodies for Brain Delivery of Biologics. Pharmaceutics 15 (2023).
Profile
Required
The successful candidate:
- Should hold a PhD degree in neuroscience biology chemistry engineering or a related field
- Should be creative enthusiastic critically thinking and motivated
- Ready to work against stringent deadlines
- Enjoys teamwork and has excellent oral and written communication skills in English.
Appreciated
- Experience working with laboratory mice (FELASA B)
- Project management and effective communication skills
- Knowledge of the literature on neurodegenerative disorders
- Good understanding of antisense oligonucleotide therapies
- Interested in brain delivery of drugs
- Good publication record
We offfer
- An exceptional strong scientific environment
- Possibility to supervise students and technicians and develop an independent research profile
- Access to stateoftheart infrastructure
- A stimulating diverse international worldclass research environment
- Animal models expertise in neurodegenerative disorders
- Financial support is available for at least 2 years (renewable one year contract). However the successful candidate is encouraged to obtain a personal fellowship (MarieCurie HFSP EMBO or National funding organizations).
- Start date: as soon as possible the position is available immediately
How to apply
Motivated candidates with a strong interest in neurodegeneration and with a strong commitment to basic research are invited to apply. Please complete the online application procedure and include a CV a list of publications a summary of past research and the contact information of 2 to 3 referees. The bestranked candidates will be invited for an interview.
For additional information concerning this position please contact Bart De Strooper () or Maarten De Wilde ()
- Find out more about the De Strooper lab via this link
- Find out more about the De Wilde via this link
- Connect through our LinkedIn page
- Discover the Center by visiting the website or looking around in our a virtual tour
- Follow the Center on social media: Facebook Instagram and X
Employment Type
Full Time
