Senior Biochemist Biopyhsicist mfd

Indivumed Therapeutics is a biotech company focused on precision oncology. We look back on over twenty years of innovation driven by a vision that remains unchanged to this day: To enable precision therapy that offers a cure for every cancer patient.
Striving for this goal we have unlocked an understanding of the molecular reality of cancer at an unparalleled level that is now supporting the identification of novel targets to partner with the pharmaceutical industry to develop precision cancer therapeutics.
Whether as a scientist or a mathematician as a data analyst or in a corporate function there are many ways you can contribute to our purpose. As a visionary international company we provide ample opportunities for your professional advancement and career development along the way.

Join us in shaping the path to precision cancer therapy.

Currently we are seeking a motivated and innovative Biochemist and/or Biophysicist to join our Target Characterization group. As a scientist you will be an integral member of the group and play an active role in pharmacological target characterization and screening for hit identification in the field of pharmacooncology (molecular cancer therapy). You will participate in efforts to develop and integrate cellfree and/or cellbased functional assays in small molecule screening campaigns to support our targetbased drug discovery process with focus on the areas of unmet therapeutic need such as colon and lung cancer. Based on a good understanding of stateofthe art drug screening methods you are expected to contribute to the generation of biochemical tools that effectively enable development of firstinclass therapeutics against a validated target.

Your responsibilities:

• This is a labbased position with more than 75% of time expected to be spent in screening and characterizing protein targets and developing assay protocols.
• You will lead the implementation of small molecule ligand screening campaigns for hitidentification using the developed cellfree and cellbased assay platforms and contribute to the generation of the associated patent application.
• As an experienced scientist in the field of ligand screening using biophysical methods you will use purified proteins or relevant protein domains for biophysical ligand screening and ligandtarget interaction characterization (including SARtype experiments) using techniques such as differential scanning fluorimetry fluorescence polarization FRET isothermal titration calorimetry or microscale thermophoresis.
• You will also engage and supervise external vendors performing surface plasmon resonance and NMR experiments on our behalf.
• You will collaborate closely with the medicinal chemists and theoretical biophysicists performing virtual ligand screening and modelling part of SAR and also actively engage with a team of biochemists purifying the proteins and performing the biochemical assays.
• You also will troubleshoot and support new project needs as an assay development expert independently and in collaboration with colleagues.
• You will be responsible for drafting SoPs data generation analysis/interpretation and communicate the results effectively orally and in writing.
• You will manage and mentor Research analysts if assigned.
• Last but not least you will contribute to departmental administration and ensure proper maintenance of records in accordance with policies.

Our requirements:

• PhD in biochemistry biophysics or chemistry after studying biology biochemistry molecular medicine or comparable subjects
• At least 3 years of postdoctoral experience in biophysical methods listed above and experience in the establishment of screening procedures for target molecules in cellfree and cellbased systems (essential)
• Broad knowledge and strong background in assay development techniques for a range of protein target classes (enzymes receptors ion channels etc) and stateofthe art fluorescence luminescence and absorbance detection methods
• Scientifically creative and resultsoriented with attention to detail and expertise in common data analysis and management software (Prism imageJ eLN etc)
• Excellent communication skills in English and German

Your benefits

• Demanding area of responsibility in a fastgrowing company
• Grant for the HVV ProfiTicket/Deutschlandticket
• Subsidy for sports membership and events
• Company pension scheme
• Company doctor
• Fresh fruits and drinks
• Christmas and summer party
• Flexible working hours
• German and English courses
• 30 days holiday
• The 24th and 31st of December are holidays and wont be deducted from your annual holidays.

Would You Like to Contribute to the Success of Our Company

Please apply online and include your salary expectations and current notice period.