Research Scientist Biochemist
Research Scientist Biochemist
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Job Description
Responsibilities
Take a lead role in the expression and purification of recombinant proteins including multipass membrane proteins for structural studies.
A key aspect of this position will be communication both within the protein group and across multiple disciplines (project teams enzymologvists crystallographers and CADD groups) ensuring that information on work progress is relayed in a clear manner highlighting any technical issues and providing potential solutions.
Keep abreast of and implement technology developments within the area of protein expression and purification especially techniques involved in the production of recombinant proteins including multipass membrane proteins.
Requirements
PhD holders or highly experienced Bachelor/MSc degree holders. Preference will be given to candidates who have spent time working within labs recognised for their expertise in the field of multipass membrane proteins.
We are looking for candidates who can demonstrate the following skill sets:
PhD holders or highly experienced Bachelor/MSc degree holders.
Familiar with insect and mammalian cell expression systems.
Fully independent in purification techniques (affinity chromatography ion exchange SEC and HIC).
Extensive working knowledge of AKTA purification platforms and associated software.
Comprehensive knowledge and experience with software used in manipulating protein and DNA sequences (VNTI) and molecular visualisation of proteins (PyMOL or similar).
An excellent knowledge of the literature around the generation of recombinant proteins including multipass membrane proteins for structural studies.
In addition all applicants must possess excellent written and verbal communication skills.
We are currently seeking an experienced protein biochemist with expertise in the expression and purification of a variety of recombinant proteins including integral membrane proteins for use in structural studies to join our Protein Expression & Purification Department. The successful candidate will have the opportunity to make a significant scientific contribution to exciting drug discovery projects. As well as a track record of working with multi-pass membrane proteins, the individual should have an excellent understanding of their structure and function.
Employment Type
Full Time
