Center for Medical Biotechnology CMB PhD program

About VIB

VIB is an entrepreneurial nonprofit research institute with a clear focus on groundbreaking strategic basic research in life sciences and operates in close partnership with the five universities in Flanders Ghent University KU Leuven University of Antwerp Vrije Universiteit Brussel and Hasselt University. VIB is an independent research institute of the government with about 1900 scientists from more than 77 countries.

About VIBUGent Center for Medical Biotechnology

The VIBUGent Center for Medical Biotechnology (CMB) focuses on the development of new and innovative molecular tools and technologies to challenge human health problems. The Center translates its novel technologies and insights to widely applicable research tools vaccines diagnostics and biopharmaceuticals. Our research pushes the boundaries of protein and DNAfocused biomolecular and bioinformatics research and engineering technologies. CMB educates and trains the next generation of medical biotechnology researchers and informs the public on the impact of biotechnology on human health.

PhD projects

Multiome exploration of different liquid biopsy fractions for cancer diagnosis and monitoring Lab De Preter & lab Gevaert

Analysis of nucleic acids (DNA and RNA) and proteins in liquid biopsy samples of cancer patients has been significantly revolutionized over the past decade. As a result it has become an important novel minimally invasive approach for cancer diagnosis prognosis prediction and monitoring. During the past years the team of Katleen De Preter has gained analytical and computational expertise in the isolation quality control and analysis of cfDNA (circulating cellfree DNA) isolated from blood plasma. The team of Kris Gevaert has recently developed a highthroughput protocol for isolation of EVs (extracellular vesicles) for proteomic analysis and has implemented plasma proteome profiling including profiling of cytolysis proteins in their workflows.

Recently both teams have joined forces to develop a copurification protocol of EVs and cfDNA and to investigate the proteome and nucleic acids in EVs. In this PhD project we want to investigate and compare the protein DNA and RNA content in different liquid biopsy fractions including the circulating cellfree fraction and the EVfraction. More specifically we want to investigate the tumoral derivatives in these different fractions through computational analysis of omics data. In addition we will integrate the multiomics data and investigate the potential of the integrated data in cancer diagnosis and monitoring. In this project data will be generated on cell culture medium from EVsecreting cell lines blood plasma from patientderived xenograft models as well as clinical samples from cancer patients.

Discovery and characterization of single domain proteins with broad antiinfluenza virus activity Lab Saelens

Human influenza typically presents as yearly epidemics during the winter season in moderate climate zones. In addition influenza pandemics can occur when a humantohuman transmissible influenza A virus that is antigenically very different from previously circulating viruses emerges. This project aims to isolate singledomain proteins that can broadly neutralize influenza A viruses. In addition the mode of action of these candidate paninfluenza inhibiting biologics will be determined. Finally structureguided formatting will be applied to these singledomain proteins to achieve optimal antiviral potency and breadth. This PhD research project thus contributes to pandemic preparedness.

What we are looking for

• You have a Masters degree in the field of life sciences with a focus on bioinformatics biomedical sciences bioscience engineering (bio)chemistry (molecular) biology biotechnology medicine or related disciplines.
• You have analytical problemsolving skills you are a team player creative critical and openminded.
• You have excellent oral and written communication skills in English.
• You are eligible to apply for a grant with our local science foundation by March 1st 2025 (do note criteria: or ). You will be required to write a proposal to secure such fellowship funding together with your group leader.
• For the research project in De Preter and Gevaert lab candidates should have knowledge and/or wet and drylab expertise in genomics transcriptomics and/or proteomics analyses.

What we can offer you

• A working environment with enthusiastic fellow Ph.D. students technicians postdocs and group leaders.
• Swift access to stateoftheart tools and infrastructure that are needed to fulfill your Ph.D. project.
• A stimulating and supportive international research environment.
• Institutional training opportunities to broaden your expertise and skills

How to apply

For more information please contact Nele Vervaet ().

Please apply online and upload your resume and motivation letter:

Your application must include the following documents. Only applications that contain all required documents and information will be considered for selection.

• A cover letter in which you specify and motivate the research topic of your choice
• Your CV and an overview of your study results (merged into one pdf file).
• Your diploma with the required degree (if already in your possession). If you have a foreign diploma in a language other than our national languages (Dutch French or German) or English please add a certified translation in one of the mentioned languages.

Note that the maximum file size for each field is 10 MB.

As VIB and Ghent University maintain an equal opportunities and diversity policy everyone who satisfies the eligibility criteria is encouraged to apply for this position.