Senior ResearcherScientist PK PKPD

ProQR Therapeutics is a biotechnology company listed on NASDAQ with offices in Leiden, the Netherlands, and Cambridge, Massachusetts, ProQR is focused on the development of life-changing RNA therapies to meet the unmet need of individuals and families with common and rare A team of 120 enthusiastic ProQRians from all walks of life and more than 30 different nationalities is up to this We have the passion and commitment to make a difference in the lives of the communities we Our proprietary Axiomer RNA editing technology platform enables the editing of specific single nucleotides in RNA using the cell s own editing Axiomer RNA editing technology harnesses ADAR (Adenosine Deaminase Acting on RNA), which is machinery present in all human cells to repair G-to-A mutations, modulate protein, and enable protective mutation Axiomer could potentially yield a new class of innovative medicines and treat currently untreatable

ProQR is currently recruiting a life science professional (Researcher / Scientist) with expertise in drug metabolism and pharmacokinetics (DMPK) and pharmacokinetic-pharmacodynamic (PKPD) modeling to join the Preclinical team (full-time position). The Preclinical Team is responsible for vitro safety screening and for all animal studies, including pharmacodynamic (PD), pharmacokinetic (PK), toxicity evaluation, and Generation of PK and PD models to describe the exposure (dose)-response relationship of a candidate will guide dose regimen selection and support preclinical and clinical development In your role, you will be reporting to the VP Toxicology and DMPK / Head Preclinical

Location: Leiden, NL

The role:

The subject matter expert will be responsible for the evaluation of PK and the development of PKPD models in the current early research programs, as well as future development The successful candidate is an enthusiastic and creative team player and will work closely with other colleagues in an interdisciplinary team environment to progress the translational science in ProQR s

The activities include:

• Design PK and PKPD strategies in research and development programs
• Analyze PK and PD datasets with appropriate modeling software to understand pharmacokinetics, dose exposure, and exposure-response relationships
• Interpret non-clinical PK data to contribute to the selection of starting doses and exposure predictions for first-in-human clinical trials
• Evaluate or simulate dosing regimens in animal and early clinical studies to support dose regimen selection
• Planning, outsourcing, and monitoring of animal PKPD studies, according to agreed timelines
• Write PK, PKPD, and /or modeling and simulation components of study protocols and reports
• Ensure budget compliance

Required qualifications:

• An advanced degree (HBO / Master level or PhD) in life sciences, clinical pharmacology, or pharmacokinetics with 2 to 5 years of relevant working experience in a life science environment (preferential biotech/pharma industry)
• Knowledge and experience in nonclinical/clinical DMPK
• Working knowledge of PKPD software (eg WinNonlin required; other software like NONMEM and R preferred)
• Team player, with a hands-on and can-do mentality,
• Flexible attitude, being able to work in a fast pace and dynamic environment
• Pro-active and pragmatic self-starter, with a result-oriented & problem-solving mindset

Preferred qualifications: Knowledge and experience in toxicology, regulatory (ICH&GLP) guidelines, and bioanalytical techniques like HPLC and LCMSMS

ProQR as an employer

As an employer, we are true believers in the value of a workforce in which people from diverse backgrounds are encouraged to develop themselves, personally and We believe that happy and energized people, working well together in an environment in which they thrive, will do phenomenal and awesome

We are committed to ensuring that no employee, candidate, or job applicant receives less favorable treatment on the grounds of race, age, disability, pregnancy, religion, gender identity and expression, sexual orientation, marriage, or civil partnership At ProQR we want to create an inclusive culture where everyone can be valued for who they are and in which individual differences and contributions in all forms are recognized and

We offer an exciting and innovative working environment in a very committed organization, with the following benefits:

• A competitive salary
• 8% holiday allowance
• 30 vacation days
• An annual performance bonus
• Stock options
• A premium-free pension plan
• A commuting allowance
• A subsidized staff restaurant
• Flexible working arrangements
• Unlimited (un)healthy snacks and drinks
• Employee events (boot camp, Hipster caf , and other social events)

Do you want to be part of our devoted team of enthusiastic professionals? Do you think you can contribute to achieving our mission? Do you want to work in a challenging & dynamic biotech environment where your work can really make a difference? If so, we re looking forward to receiving your application by filling out our application

You can contact Silvia Catellani via if you have any

Please note that screening is part of our selection