Sr Computational Biologist

CK Group are seeking a highly skilled and motivated Senior Computational Biologist to join our clients research team in our mission to serve patients with intractable cancers.

This role is an on site position, full time and on a permanent basis, located in Waltham, MA.


The Company:

The company are developing therapeutics for patients with challenging, complex cancers. They employ a single cell sequencing platform to dissect the biology of immune cells in human tumors and identify novel, exciting oncology targets.

They are currently advancing multiple programs toward early human studies. The company is a growing vibrant team of scientists who are proactive, thoughtful and bring a "can-do" attitude to the lab.


Job Summary:

The successful candidate will be responsible for analyzing early-stage biomarker and multi-omics data, mining publicly available data sources, and designing experiments to validate model predictions. This role requires communicating computational results and outcomes to a multidisciplinary team of scientists, external collaborators, and partners.


Job Responsibilities:

• Leverage understanding of clinical disease/biology to drive and test hypotheses. Collaborate very closely with translational, clinical, and preclinical immunology teams.
• Design, implement, and document algorithms and pipelines, ensuring their alignment with the objectives of ongoing and future projects.
• Formulate research hypotheses and develop computational methods to enhance biological interpretation of predictive models.

Qualifications And Education Requirements:

• PhD, MS, or equivalent in computational biology, genomics, biology or related discipline.
• Experience with analyzing and interpreting preclinical and clinical biomarker datasets and mining publicly available data. Demonstrated ability to generate biological insights from omics data, through peer-reviewed publications or relevant work products.
• Track record of completed scientific projects as evidenced by publications and preprints.
• Familiarity with drug screening databases (CTRP, GDSC, PRISM) and publicly available cancer datasets (CCLE, DepMap, TCGA, AACR Project GENIE, etc.).
• Deep understanding of biostatistics and data analysis tools.
• A critical mindset for data integrity, quality assurance, and documentation.

Apply:

It is essential that applicants hold entitlement to work in the US. Please quote job reference 104981 in all correspondence.